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Cell migration and wound-closure assays (such as scratch assays in fibroblast or endothelial cell cultures) are standard in vitro models for studying this combination's proposed tissue-repair pathway effects, typically comparing single-compound versus combined-compound treatment conditions
The chondrocytes used in this study were isolated from eight donors (15-, 70-, 73-years-old female, and 42-, 69- and 70-years-old male) without the sign of cartilage degradation
It actually exists in human plasma - the problem is, it declines with age
