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Calorie restriction mimetics: an emerging research field

It has a short half-life in blood of 1.5-3 min due to a high clearance but also activates afferent nerve endings directly before entering the blood

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The solved X-ray crystal structure of tetrameric MSA-DH reveals the key catalytic residues Cys 290 and Glu 256 , accessible through opposing substrate and cofactor funnels