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Nasal spray considerations: Typically lower bioavailability than injection, requiring somewhat higher doses Faster onset in some users due to direct CNS access More convenient and less intimidating for needle-averse individuals Requires properly calibrated spray bottles for accurate dosing Converting from injectable to nasal dosing is not straightforward

Persistent activation of both microglia and astrocytes creates an environment that supports ongoing neuronal damage, leading to chronic neuroinflammation and cognitive deficits

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