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Strikingly, the CCR8-specific viral chemokine antagonist MC148, with a reported affinity similar to CCL1 61,62 , has a short N-terminus of only 5 amino acids, which contains a triplet of basic residues (Supplementary Fig
These continuously generated electrophilic hydroperoxy-phospholipids are neutralized by a specific GSH-dependent peroxidase, glutathione peroxidase 4 (GPX4), which prevents them from damaging membranes and driving ferroptotic cell death (7, 8)
ZBTB20-mediated titanium particle-induced peri-implant osteolysis by promoting macrophage inflammatory responses
Treatment decisions should be individualized, considering disease severity, nutritional status, symptom burden, and patient preferences
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