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Compromised healing environments : Perhaps most intriguingly (and this is what catches my attention as a surgeon), BPC-157 appeared to promote healing even in situations where recovery was impaired, such as tissues affected by corticosteroid use or areas with very poor blood supply
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Additionally, activation of the ubiquitin-proteasome system and the lysosomal system leads to increased proteolysis and, accordingly, muscle destruction via up-regulation of atrogin-1 , MuRF-1 , cathepsin-L , PDK4 , p21 , Gadd45 and 4E-BP1 [60, 61]
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