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Surprisingly, adipocyte-selective deletion of the insulin receptor improves glucose tolerance despite the impairment of glucose uptake in adipose tissue [28]

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Moreover, similarly to the dual GIPR/GLP-1R agonist, LY3437943 reduced blood glucose and plasma insulin, suggesting potential improvements in insulin sensitivity

Inflammatory mediators Tissue injury, however minor, initiates a localised inflammatory cascade involving histamine, prostaglandins, and cytokines, which sensitise nerve endings and cause the characteristic burning or stinging sensation