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Activation of large-conductance (BK Ca ) and small-conductance (K Ca ) K + channels, as well as ATP-sensitive K + (K ATP ) channels, induces K + efflux, reducing Ca 2+ entry through voltage-gated calcium channels (VGCCs), leading to pericyte hyperpolarization and increased CBF [93]
10.1371/journal.pgen.1000020 45 PfannenstielS.PraetoriusM.PlinkertP.BroughD.StaeckerH
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Laboratory studies have also shown that it can reduce the body's response to acute stress, as it significantly affects the levels of substance P, beta-endorphin and cortisol in the hypothalamus and blood plasma
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