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These formulations are not FDA-approved and may carry different safety and efficacy considerations

Biopsy-proven NASH : Patients with histologically confirmed NASH, particularly those with significant inflammation or early fibrosis (F1-F2), may be considered for off-label GLP-1 therapy, especially if they have failed lifestyle modification or have contraindications to other therapies like vitamin E or pioglitazone

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This combined deficit can become extreme, driving excessive lean mass loss