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Appetite and food reward 3-arm Phase 1 tirzepatide vs liraglutide 3.0 mg vs placebo: measured lunch intake fell 524.6 kcal vs placebo by week 3 (about 72% of that difference remained at week 6), with craving and hedonic-hunger reductions exceeding liraglutide
the net effect on bowel habit varies by individual and dose
Studies demonstrate the peptide participates in transcriptional regulatory mechanisms common to both the pineal gland and retinatissues sharing common embryonic origin and similar peptide responsiveness
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