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Vildagliptin and sitagliptin could prevent mitochondrial dysfunction in the brain and improve learning behavior in high-fat diet-induced IR rats (82)
What they found (summary): MC1R: melanogenesis, pigmentation, anti-inflammation MC2R: ACTH receptor in the adrenals (Melanotan II does not act) MC3R: energy, cardiovascular function, anti-inflammation MC4R: appetite (central control), sexual function, autonomic regulation MC5R: exocrine glands (sebaceous, lacrimal, salivary) Mutations in MC4R are the most common monogenic cause of obesity in humans Why it matters: Cones review article is the reference article for all of melanocortin pharmacology
Whats next for methylene blue research My current focus is on finding ways to use methylene blue for pain management
It essentially frees up more NAD+ (a vital coenzyme in metabolism), which revs up the bodys ability to burn calories and fat
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