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If a clinician is considering dual-hormone therapy, ask what evidence applies to your situation
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4 The dose increases on a fixed schedule to let the body adjust to each dose
Statistical analysis Statistical analyses were conducted using IBM SPSS Statistics software (version 26.0, IBM, Chicago, IL, USA) and GraphPad Prism (version 8.2.1, GraphPad Software, San Diego, CA, USA) for data visualization
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