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Mass spectrometry (MS) confirmation: The COA should confirm the observed mass matches the expected molecular weight of 850.9 g/mol (or the protonated [M+H]+ ion at 851.9 for electrospray ionization MS)
in fact, their weight reduction was less pronounced than that of those on the lower dose
The release of sonic hedgehog (SHH) by astrocytes acts on ECs to modulate TJ protein expression and maintain BBB integrity (Daneman and Prat, 2015
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