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Although SUMMIT also demonstrated a reduction in the composite endpoint of cardiovascular death or worsening HF events, the magnitude of the improvement, specifically in the KCCQ-CSS observed with higher-dose semaglutide (STEP-HFpEF
Moreover, GLP-1 may influence the composition and function of the gut microbiota, which plays a pivotal role in IBD pathogenesis [384]
Others are extrapolations from animal data that have not been studied in humans
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