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This approach is supported by FDA guidance on GLP-1 receptor agonist class labeling for semaglutide in renally impaired patients [11] and by the general pharmacodynamic rationale that slower CNS adaptation reduces nausea burden [10, 12]
You might notice that your appetite suppression is stronger when you inject in the abdomen versus the thigh
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When the medication is initially prescribed, starting low and going slow can also help your patients better tolerate any GI symptoms associated with GLP-1RAs. A better understanding of the side effects is key when prescribing any medication, and it is equally important to raise patient awareness
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