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Mittal et al

For most adults, initial dual therapy is recommended: Metformin + SGLT-2 inhibitor Treatment should then be individualized based on comorbidities: Atherosclerotic cardiovascular disease: consider adding GLP-1 receptor agonists such as semaglutide Chronic kidney disease: SGLT-2 inhibitors remain foundational, with DPP-4 inhibitors as additional options when needed

Many people prescribed GLP-1 receptor agonists for type 2 diabetes or weight management wonder whether they'll need to take these medications indefinitely