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Consistently, IGF-I administration to rodents increases kidney growth, renal blood flow and glomerular filtration rate (GFR)[138, 141, 142], and similarly, GH and IGF-I also increase renal blood flow and GFR in humans[143], suggesting that IGF-I may be a physiologic regulator of renal function

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The analysis results of multiple public datasets indicate that the expression of the major methionine metabolic enzymes is related to hepatocyte nuclear factor 4 (HNF4)