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This bidirectional regulation suggests sophisticated sensing of tissue microenvironmental cues, enabling GHK-Cu to normalize MMP activity toward homeostatic levels rather than exerting uniform stimulatory or inhibitory effects
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Exposure of cells of the Co-hyperaccumulator Crotalaria cobalticola and non-accumulators Raufolia serpentina , and Silene cucubalus to Co-ions resulted in an increase of citrate, indicating the involvement OA in the complexation of metal ions (Oven et al., B
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