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Among these, compounds 41 and 42 (Figure 29), which possess hydrophobic side chains, exhibited the most potent NO inhibitory activity and showed a stronger inhibitory effect on the production of TNF-, IL-1, and IL-6 compared to indomethacin and celecoxib

This leads to a scenario where new therapeutic strategies for diabetes must inevitably consider not only glycemic and weight control but also the reduction of both vascular and non-vascular complications