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It works by improving fat metabolism, increasing insulin sensitivity, and providing significantly greater weight loss compared to single-agonist peptides such as semaglutide (Ozempic and Wegovy), liraglutide, and dulaglutide
The cancelled 2015 Phase I trial (NCT02637284) was almost certainly abandoned for this reason rather than buried by a regulator
Capture times identify archived source observations
however, an increase in gastrointestinal adverse events was observed in the tirzepatide group compared with dulaglutide
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