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Common schedule: Starting dose: 0.25 mg weekly Increase every 4 weeks Maintenance: up to 2.4 mg (Wegovy) How to take: Same day each week With or without food Injection sites: abdomen, thigh, upper arm Side Effects of Semaglutide Common: Nausea Vomiting Constipation Diarrhea Decreased appetite Monitoring: Patients are monitored for: tolerance weight loss progress overall health Semaglutide vs Tirzepatide Semaglutide targets GLP-1 receptors, while tirzepatide targets both GLP-1 and GIP
GLP-1 receptor agonists work by mimicking the incretin hormone GLP-1, which enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and reduces appetite through central nervous system pathways
older age, and higher fasting NEFA concentrations) are determinants of enhanced GLP-1 secretion
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