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Each new identified PD axis satisfied the criteria developed to identify the IU direction, as described in Section 2.3, and drug delivery simulations were performed following the methods laid out in Section 2.2

Nevertheless, since the risk of cardiovascular and renal events will remain even with the use of GLP-1RA, there is a great deal of clinical interest in its combined use with SGLT2i and finerenone (Table 4)

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