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Our previous study, BARI-OPTIMISE, selectively recruited participants with suboptimal weight loss after MBS who also had a blunted meal-stimulated GLP-1 response, based on observational study data correlating higher native postprandial GLP-1 levels to higher %WL after MBS
It was also compared to a placebo, a GLP-1 receptor agonist (semaglutide) and two long-acting insulin analogues
Follow up lab work will be at the discretion of the doctor.
We cant say that GLP-1s are actually causing these symptoms, says Neil Sehgal, the studys first author and a doctoral student in CIS advised by Guntuku and Ungar
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