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The neurotoxin MPP + , a metabolite transported into dopaminergic neurons via the dopamine transporter, accumulates in the mitochondria and inhibits complex I activity of the electron transport chain, reducing ATP production and increasing ROS release, ultimately causing degeneration of dopaminergic neurons in the substantia nigra and striatum (46)
In Study A, women receiving PT-141 three times daily for 15 days exhibited significantly greater body weight reduction compared to placebo (1.3 kg difference) with high statistical significance
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