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Clinical trials have shown that both of these medications can increase the frequency of bowel movements in individuals with chronic constipation and constipation-predominant irritable bowel syndrome (IBS-C) (Lee 2014
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Simultaneously, several meta-analyses and guideline panels highlight that many claimed indications are supported only by low- to moderate-quality evidence, with significant heterogeneity between trials and frequent failure of some strains or formulations to demonstrate superiority over placebo in rigorous, well-controlled studies (2, 3)
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