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The three most common causes: (1) peptide degradation due to improper storage (temperature excursions above 8C after reconstitution), (2) complete avoidance of UV exposure (MT2 requires UV to trigger melanosome transfer), or (3) dosing below the melanogenic threshold (fewer than 0.25mg per injection or inconsistent dosing frequency)
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society , 19 (5), 426431
Identification of the gene responsible for the cblA complementation group of vitamin B12-responsive methylmalonic acidemia based on analysis of prokaryotic gene arrangements
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