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This is a later sign, appearing when B12 deficiency has persisted for a long time
For example, the redox activitiy of p66Shc within mitochondria has been shown to generate H 2 O 2 in the absence of superoxide through oxidation of cytochrome c (Giorgio et al., 2005)
While these options may help some people enter care more easily, barriers such as cost, coverage and awareness still exist
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