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There were also differences across trials
Research shows that when people stop taking GLP-1 medications, their appetite and weight typically return
Similarly, the large jump from 1.0mg to 1.7mg can be split into 1.25mg followed by 1.5mg followed by 1.7mg for people with sensitive gastrointestinal systems
The injectable route does offer better bioavailability since it bypasses first-pass metabolism in the gut and liver, but the total weekly dose from a compounded tirzepatide injection remains well below what studies have used to demonstrate significant metabolic effects
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