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It functions by binding to the hydrophobic pocket of the RIPK1 kinase domain (Degterev et al., 2008), preventing its dimerization and necroptosis activation
Synthesis and characterization of platinum(IV) anticancer drugs with functionalized aromatic carboxylate ligands: influence of the ligands on drug efficacies and uptake
2023 Aug 26;402(10403):720-730
Thus far, the only detailed data available on the use of the peptide comes from a single group in Russia, albeit from a well-respected one
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