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In order to clone the GLP-1 receptor Thorens drew on the expertise that he had picked up from cloning the GLUT2 gene which encodes for a protein that helps to transport glucose across cell membranes
From a baseline mean body weight of 92.2 kg, the highest mean weight loss observed was 19.7%, about 17.5 kg, compared to 2.0%, about 1.6 kg, for placebo after 24 weeks of treatment
Zipor and Oren-Shamir 2013
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