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The caloric deficit also means reduced protein availability for tissue synthesis, reduced micronutrient availability, and potentially reduced copper delivery to the enzymatic systems that GHK-Cus carrier function bypasses
The CBP lysine acetyltransferase is a well-recognized, direct NRF2 binding partner (Tonelli et al, 2018), contributing to NRF2 transcriptional activity at reporter genes (Katoh et al, 2001) and responsible for acetylating NRF2 itself (Sun et al, 2009)
doi:10.3109/03602532.2011.558093
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