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2 CREX) and comprising 790 individuals (SI3 - Fig

Downregulation of the Basal Metabolic Rate As the body realizes it is enduring a prolonged famine state due to the medication-induced caloric deficit, it undergoes adaptive thermogenesisa systemic downregulation of the Basal Metabolic Rate (BMR)

V.MissiaenR.EliaI.BrningU.et al (2018)

While just over 30% of people on Wegovy made it on their medication to the one-year mark in 2021, the year it was approved for weight loss, that figure had nearly doubled by 2024