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The combined GI side effects could be severe

PMID: 39028822 Sci Adv Microglial Ffar4 deficiency promotes cognitive impairment in the context of metabolic syndrome

Niacinamide is a form of vitamin B3 with a wide range of benefits, including supporting the skin barrier and minimizing the look of fine lines

Vitamin B12 supplements (not clear if this refers to physiological or pharmacological doses) lower the blood levels of homocysteine in the blood, which may be linked to increased risk of stroke or heart attacks, although the relation between vitamin B12 supplementing and lower rates of heart attacks has not been confirmed