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At study completion, the mice were euthanized and the tumors were extracted
Morbid obesity : Cap the dose at 100 kg body weight
The mice were housed at a constant temperature and humidity under a 12-h/12-h lightdark cycle with free access to standard food and water for at least 1 week prior to the beginning of the experimental procedures
Intact AMG 133 shows faster mean clearance than total AMG 133 (0.568 versus 0.367 ml h 1 kg 1 )
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