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GSTs are able to conjugate glutathione (-l-glutamyl-l-cysteinyl-glycine, GSH) to a wide range of hydrophobic and electrophilic molecules including many carcinogens, therapeutic drugs, and many products of oxidative metabolism, making them less toxic and predisposed to further modification for discharge from the cell (Fig
It also nudges the skin toward making a lighter type of pigment instead of a darker one
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An Untargeted Metabolomics Approach on Carfilzomib-Induced Nephrotoxicity
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