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In this way, the rate of ROS production exceeds the antioxidant ability of ROS buffering, leading to increased oxidative stress
This delayed gastric emptying can lead to a prolonged feeling of fullness, which may affect nutritional intake and energy levels throughout the day
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In vivo studies, such as that by Morris et al., used a preclinical model of a high-fat diet in infant rats to mimic insulin resistance, identifying impaired nigrostriatal dopamine function as a consequencea hallmark of PD neuropathology [152]
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