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FDA has documented over 400 adverseevent reports with compounded semaglutide and 300 with compounded tirzepatide, though the Alliance for Pharmacy Compounding disputes the reliability of those data
56 , Wibisono et al
These bispecific molecules that antagonize GIPR and agonize GLP-1R pathways led to decreases in BW and improvements in metabolic parameters in obese mice and monkeys 34
Furthermore, the uptake correlated with systemic levels of high-sensitivity C-reactive protein (CRP), supporting that semaglutide may reduce atherosclerotic inflammation by decreasing activated macrophage activity [36]
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