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A) Backbone modifications Backbone modifications are the earliest structural modification method in the field that targets the masking or removal of amide bonds in the peptide backbone
These medications are generally recommended for individuals who are overweight or obese, especially if they have additional health risks like type 2 diabetes or metabolic syndrome
Digestion slows slightly, prolonging fullness: GLP-1 gently slows gastric emptying, meaning food stays in the stomach longer
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