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In vitro studies have shown that addition of DPP-4 is associated with impaired insulin signaling in primary human adipocytes, skeletal muscle, and smooth muscle cells (79), while conversely, silencing Dpp4 (using short interfering RNA) resulted in improved adipocyte insulin responsiveness (89)
Dulaglutide and Liraglutide : While effective, these medications may result in slightly less weight loss compared to Semaglutide and Tirzepatide, with average reductions around 5-10%
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