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A maximum of 4 burr holes, 2 in each hemisphere, were used to inject pLKO_EGFP_Lox-STOP-Lox_ Gsto2 -shRNA or scrambled shRNA viral vectors by following specific stereotaxic coordinates

Membranes were probed using antibodies to FoxO1 (1:2500, 18592-1AP, Proteintech, Chicago, IL, USA), SOD2 (1:6000, 66474-1lg, Proteintech, Chicago, IL, USA), NOX4 (1:600, 14347-1-AP, Proteintech, Chicago, IL, USA), and -actin (1:2000, AM10218-400, Abgent) as the primary antibodies

Acknowledgments We thank Haiyan Yu, Xiaomin Zhao and Yuyu Guo from Core Facilities for Life and Environmental Sciences of SKLMT (State Key Laboratory of Microbial Technology, Shandong University) for the assistance in LSM900 Super Resolution Laser Scanning Confocal Microscope analysis

Mild to moderate pain Protocol: BPC-157: 250mcg twice daily Duration: 4-8 weeks Method: Injectable near pain site or systemic Expected outcome: 40-60% pain reduction Improved function May be sufficient alone Severe or chronic pain Protocol: BPC-157: 500mcg twice daily TB-500: 5-10mg weekly loading for 4-6 weeks, then 2-5mg maintenance Duration: 12-16 weeks minimum Method: Injectable Expected outcome: 50-70% pain reduction Significant functional improvement Better quality of life Multiple pain sites or systemic pain Protocol: BPC-157: 250-500mcg twice daily (systemic injections - abdomen/thighs) TB-500: 5mg weekly Optional: KPV 500mcg daily if inflammation major factor Duration: 12-24 weeks Expected outcome: 40-60% overall pain reduction Improved multiple areas Better mobility Maintenance protocol After initial relief: BPC-157: 250mcg daily OR every other day TB-500: 2-5mg weekly OR biweekly Duration: Ongoing as needed Why maintenance: Prevents pain return Continues healing Safe long-term Use our peptide dosing guide , peptide dosage chart , and how to calculate peptide dosages