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The analysis of molecular dynamics (MD) simulation data over 1 s each for the GLP-1GLP-1R and the SR18GLP-1R systems, estimation of free energy of binding, including preliminary experimental studies on the synthetically prepared designer peptide, suggests that the designer peptide SR18 has strong signature traits of an agonist that can potentially trigger GLP-1R-mediated insulin exocytosis under experimental conditions in tissues

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