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These conditions all have some compelling scientific evidence for off-label treatment using GLP-1RAs
The unfortunate truth is that big risk signals (lets say the kind you get from drinking antifreeze) can be spotted from the anecdotal experience of people in the world just trying things, but small-but-serious risk signals (lets say cardiovascular disease with tofacitinib) are really hard to identify without a proper trial or a proper observational study
11 , e1005052 (2015)
Instead of genetic knockout, functional knockout of FoxO1 occurs naturally when -cells undergo LOsG/ROS stress
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