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At the level of precursor lesions such as nevi, the initial mutagenic events triggering the neoplastic transformation are represented by several mutations which lead to the activation of the MAPK pathway (such as BRAF V600E), while at an intermediate stage of tumour progression, NRAS and additional driver mutations are seen
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For patients whose health history includes cardiovascular concerns, this difference often plays a major role in what a provider may recommend
fast heartbeat, fluctuating blood pressure, dizziness, flushing, sweating
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