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ChaC1 serves as a reliable indicator for poor prognosis of certain types of gastric cancer (63) and melanoma (75,76), as well as an independent indicator for elevated risk for female germ line tumors (including breast and ovarian cancer) (77)
In addition to activating PKGI, cGMP itself contributes to smooth muscle relaxation through direct inhibition of the plasma membrane localized L-type Ca 2+ channels
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