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Abbreviations GLP1RAs: Glucagon-like peptide 1 receptor agonists PCOS: Polycystic ovary syndrome RCT: Randomized controlled trial WMD: Weighted mean difference SMD: Standardized mean difference RR: Risks ratio CI: Confidence interval SD: Standard deviations IR: Insulin resistance GI: Gastrointestinal GnRH: Gonadotropin-releasing hormone LIRA: Liraglutuide EXE: Exenatide MET: Metformin CC: Clomifene citrate NM: Not mentioned BID: Twice a day QD: Once a day COMBI: Combined group MF: Menstrual frequency PR: Pregnancy rate IVF: In vitro fertilization TBF: Total body fat BMI: Body mass index WC: Waist circumference HOMA-IR: Homeostasis model assessment-insulin resistance TT: Total testosterone fT: Free testosterone FAI: Free androgen index DHEAS: Dehydroepiandrosterone sulphate SHBG: Sex hormone binding globulin OGTT: Oral glucose tolerance test BP: Blood pressure ART: Assisted reproductive technology GDM: Gestational diabetes mellitus FDA: Food and Drug Administration EMA: European Medicines Agency HPO axis: Hypothalamus pituitary ovary axis CRP: C-reactive protein IL-18: Interleukin 18 TNF-: Tumor necrosis factor IL-6: Interleukin 6 References Yildiz BO, Bozdag G, Yapici Z, Esinler I, Yarali H

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5 As comparison, 70/30 mixed insulin aspart was shown to have a mean increased weight of 4.04 kg

GLP-1 Q.GLP-1 A. PMDA