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Imbe A, et al
A 2021 study tracking substrate oxidation in fasted subjects found that peptide agonists administered during the cortisol peak increased fat oxidation by 1822% compared to evening dosing, sustained across an 8-hour measurement window
Its only incretin-adjacent action is dipeptidyl peptidase-4 inhibition, which the article calls indirect and weaker
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Importantly, combining DKK1 antibodies with anti-PD-L1 treatment has yielded promising results in vivo, leading to significant 4T1 tumor volume reductions [165]
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