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The copper binding occurs through a square-planar pyramid configuration involving nitrogen from histidines imidazole side chain, nitrogen from glycines alpha-amino group, deprotonated amide nitrogen of the glycine-histidine peptide bond, and carboxyl oxygen from lysine
One pharmacokinetic detail worth noting: Dihexa has an unusually long half-life of approximately 12 days
And importantly, medication review matters too
However, periodic cycles can help maintain long-term effects
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