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Trulicity and Rybelsus are both GLP 1 receptor agonists for type 2 diabetes but differ significantly
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Crucially, the ROS generated during GSH degradation by CHAC1 may also cause further TP53 mutations, creating a vicious self-reinforcing cycle: CHAC1 activity promotes the very TP53 mutations that allow the tumor to exploit CHAC1s harmful effect for growth
doi: 10.1210/jc.2010-1587
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