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The SURMOUNT-1 trial for tirzepatide showed average weight loss of 15 to 22 percent of body weight across the full study population
These thresholds help healthcare providers determine risk for things like heart disease, insulin resistance, and inflammation
It is proposed that this disturbance in carnitine homeostasis is reflective of a reduction in carnitine palmitoyltransferase-I (CPT-I) activity, possibly a result of the accumulation of omega-6 fatty acids previously observed in this patient population
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