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Meanwhile, this article focuses on evaluating the evidence of the current effects of GLP-1RAs on patients body composition, muscle mass and function in clinical trials, deeply explores the dual effects and heterogeneity of its efficacy, and analyzes the translational dilemma existing between preclinical positive discoveries and clinical outcomes.Furthermore, for the elderly population, this article further discusses the tolerance and nutritional risks faced during the treatment of GLP-1RAs
Only participants who were non-smokers, were considered as low risk for cardiovascular disease with no contraindications to exercise as outlined by the American College of Sports Medicine (ACSM), who had not consumed any nutritional supplements (excluding multi-vitamins) 3 months prior to the study, and were free from orthopedic problems that would inhibit participation in upper- and lower-body resistance training exercises were allowed to participate
Statistical significance was assessed by unpaired two-tailed t-test in d, f, g-j
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