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The next decade will be pivotal in translating accumulating clinical and preclinical findings into meaningful therapies that can prevent or reverse the course of DN, ultimately improving outcomes for millions of patients
The mechanism likely involves correction of oxidative stress and modulation of glutamate signaling via the cystine-glutamate antiporter (system Xc-) [73][74]
Clinical trials demonstrate that tirzepatide users typically experience 13% greater weight loss compared to semaglutide monotherapy over equivalent time periods, though individual responses vary widely
doi: 10.1016/j.pharmthera.2009.11.005
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